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- Purity
- >= 99% (HPLC)
- Form
- Lyophilised powder
- Origin
- United States
Manufactured for laboratory research. Not for human or veterinary use. Read full disclaimer →
Retatrutide is a synthetic triple-agonist peptide investigated in research as a GLP-1, GIP and glucagon receptor agonist for studies into incretin signalling and metabolic regulation in experimental systems.
- Purity >= 99% (HPLC)
- Supplied as a lyophilised powder
- Independent batch identity and purity testing
- For laboratory research use only; not for human or veterinary use
What is retatrutide?
Retatrutide (LY3437943) is a synthetic peptide that acts as a single-molecule triple agonist of the GIP, GLP-1 and glucagon receptors, studied as a research reference standard. It is a 39-amino-acid sequence carrying a fatty-acid acylation that extends its circulating half-life, with molecular formula C221H342N46O68 and a molecular mass of approximately 4731 g/mol.
The triple-agonist design is what distinguishes retatrutide from earlier incretin peptides, which engage one or two of those receptors. It is supplied here strictly as a research chemical and an investigational tool, not for use in humans or animals.
Is retatrutide legal in the UK?
Retatrutide is not a controlled drug under the Misuse of Drugs Act 1971, and it is not an approved medicine in the UK. It has not been authorised by the MHRA for any indication and is supplied for laboratory research use only. It cannot be sold or supplied for human or animal consumption. The buyer is solely responsible for ensuring lawful and appropriate handling, and for compliance with any local rules that apply to them. See our research disclaimer for the full terms.
How do I get retatrutide in the UK?
Kovalabs supplies retatrutide as a research chemical, despatched from the UK with full batch documentation. It is offered for laboratory research use only and cannot be supplied for human consumption, and lawful, appropriate handling remains the buyer's responsibility. It is a distinct molecule from licensed medicines and is not offered as a generic, alternative, equivalent or substitute for any of them.
How is the identity and quality assured?
The principle here is to verify, not to trust. Each batch is supplied with a Certificate of Analysis reporting identity and a purity specification of 99% or greater by HPLC, alongside mass-spectrometry confirmation of the expected mass. The verified identifiers for retatrutide are CAS 2381089-83-2, PubChem CID 171390338, formula C221H342N46O68 and a mass near 4731 g/mol. Cross-check the CoA identifiers against these before relying on any material; our published certificates are available at our CoA library.
What does the research on retatrutide investigate?
Published work on retatrutide sits in metabolic and incretin-receptor pharmacology, where it is examined as a triple GIP/GLP-1/glucagon receptor agonist. That literature describes receptor activity and study design; it does not establish any outcome in humans that would justify use outside a controlled research setting, and none of it should be read as a benefit claim. The detailed evidence audit, including how the triple-agonist pharmacology is framed in the primary sources, is handled in our monograph at the retatrutide research overview, with a structured comparison against tirzepatide at retatrutide vs tirzepatide.
Synthesis and supply
Retatrutide is supplied lyophilised for reconstitution with a suitable research diluent such as bacteriostatic water, despatched from the UK with batch documentation. Notes on the different formats this compound is studied in are set out in our retatrutide pens and vials overview. For related incretin and amylin research tools, see cagrilintide, and browse the full range in our metabolic research category.
- 2D structure
- Product name
- Retatrutide
- Synonyms
- LY3437943
- Molecular formula
- C221H342N46O68
- Molecular weight
- 4731.3 g/mol
- CAS number
- 2381089-83-2
- PubChem CID
- 171390338
- Purity
- >= 99% (HPLC)
- Form
- Lyophilised powder
- Appearance
- White to off-white solid
- Solubility
- Bacteriostatic water
- Storage
- Lyophilised: store at -20C, dry and light-protected. Reconstituted: 2-8C.
- What is retatrutide?
- Retatrutide (development code LY3437943) is a synthetic acylated peptide that acts as a single-molecule triple agonist of the GIP, GLP-1 and glucagon receptors. It is supplied as a research chemical for laboratory use only, not for use in humans or animals.
- Is retatrutide a peptide?
- Yes. Retatrutide is a 39-amino-acid synthetic peptide carrying a fatty-acid acylation, with the molecular formula C221H342N46O68 and a molecular mass of approximately 4731 g/mol.
- Is retatrutide legal in the UK?
- Retatrutide is not a controlled drug under the Misuse of Drugs Act 1971 and is not an approved medicine in the UK. It is supplied for research use only and cannot be sold for human or animal consumption. The buyer is responsible for lawful handling. See our research disclaimer for full terms.
- What does retatrutide do?
- In published pharmacology, retatrutide is characterised as a triple GIP/GLP-1/glucagon receptor agonist. That work describes receptor activity and study design only; it does not establish any outcome in humans, and nothing here should be read as a claim of effect.
- Has retatrutide been shown to be safe in humans?
- Retatrutide is an investigational compound that has not been authorised by the MHRA for any indication. It has not been evaluated as safe for human use and is not intended for human use. It is supplied strictly as a research chemical.
- Is retatrutide intended for human use?
- No. Retatrutide is supplied for laboratory research use only. It is not a medicine, is not approved for any indication, and must not be used in humans or animals.
- Is retatrutide the same as Mounjaro or tirzepatide?
- No. Mounjaro and tirzepatide are licensed medicines. Retatrutide is a separate, distinct molecule supplied as a research chemical and is not a generic, alternative or substitute for tirzepatide or any other medicine. A structured comparison is covered in our research blog.
- How do I get retatrutide research peptide in the UK?
- Kovalabs supplies retatrutide as a research chemical, despatched from the UK with a Certificate of Analysis. It is sold for laboratory research use only and cannot be supplied for human consumption. Lawful and appropriate handling is the buyer's responsibility.
- Are all retatrutide preparations the same?
- No. Purity and identity vary by supplier and batch. Confirm the Certificate of Analysis reports 99% or greater purity by HPLC and that the identifiers match CAS 2381089-83-2 and PubChem CID 171390338 before relying on any material.
- What are the molecular identifiers for retatrutide?
- Retatrutide has CAS number 2381089-83-2, PubChem CID 171390338, molecular formula C221H342N46O68 and a molecular mass of approximately 4731 g/mol. Its development code is LY3437943.
- How should retatrutide be stored and reconstituted?
- Retatrutide is supplied as a lyophilised powder. Lyophilised peptide is typically stored frozen and protected from light; once reconstituted with a research diluent such as bacteriostatic water it is kept refrigerated. Reconstitution is a laboratory step and the compound is not for use in humans or animals.
- Is retatrutide prohibited in sport?
- Anti-doping status can change, so athletes and support personnel should check the current WADA Prohibited List and consult their anti-doping organisation rather than rely on a general statement. Kovalabs supplies retatrutide for research use only and makes no representation about its standing in any sport.
- Is retatrutide a steroid?
- No. Retatrutide is not a steroid. It is a 39-amino-acid synthetic peptide carrying a fatty-acid acylation, classed in incretin-receptor pharmacology as a triple GIP/GLP-1/glucagon receptor agonist. Steroids are a separate chemical class built on a four-ring sterane core. Its identifiers are CAS 2381089-83-2 and PubChem CID 171390338. It is supplied as a research chemical for laboratory use only, not for use in humans or animals.
- Does retatrutide come as a pen or a vial?
- Kovalabs supplies retatrutide as a lyophilised powder in a research vial, not as a pre-filled pen. The vial is reconstituted with a research diluent such as bacteriostatic water at the bench. Vials are labelled by milligram content as a product specification. Pre-filled pen formats are associated with licensed medicines, which retatrutide is not. Notes on the formats this compound is studied in are set out in our retatrutide pens and vials overview.
- What vial strengths of retatrutide are available?
- Kovalabs supplies retatrutide as a lyophilised research powder in 10mg, 20mg and 40mg vials. The milligram figure is the total peptide content of the vial, a product specification rather than any guidance on use. Each batch ships with a Certificate of Analysis reporting a purity specification of 99% or greater by HPLC. The material is for laboratory research use only and is not for use in humans or animals.
No third-party batch reports have been uploaded for this product yet. Reports are issued by independent labs after each manufacturing batch.
Calculator
Research planning only
Concentration5.00 mg/ml
Volume to draw0.050 ml
Insulin syringe (100 IU/ml)
5.0units
For research planning only. Not medical, dosing, or therapeutic advice. All Kovalabs products are research-use-only.
Store unreconstituted vials at −20°C for long-term, or refrigerated at 2-8°C for short-term use. Avoid repeated freeze-thaw cycles.
Reconstitute with bacteriostatic water down the inside wall of the vial; gently swirl to dissolve. Do not shake.
Once reconstituted, refrigerate at 2-8°C and use within 2-4 weeks. Discard if cloudy, discoloured, or particulate.
