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GH Axis
IGF-1 LR3
- Purity
- >= 99% (HPLC)
- Form
- Lyophilised powder
- Origin
- United States
Manufactured for laboratory research. Not for human or veterinary use. Read full disclaimer →
IGF-1 LR3 is a synthetic long-arginine-3 analogue of insulin-like growth factor 1, studied in research into IGF-1-receptor signalling and cellular-growth pathways in experimental models.
- Purity >= 99% (HPLC)
- Supplied as a lyophilised powder
- Independent batch identity and purity testing
- For laboratory research use only; not for human or veterinary use
What is IGF-1 LR3?
IGF-1 LR3 (Long R3 IGF-1) is a recombinant 83-amino-acid analogue of insulin-like growth factor 1, identified by CAS number 946870-92-4. It differs from native IGF-1 by an arginine substitution at position 3 and a 13-residue N-terminal extension. It is supplied as a lyophilised solid for laboratory research only.
It carries the molecular formula C400H625N111O115S9 and a molecular weight of 9117.6 g/mol. As a large recombinant protein it has no small-molecule 2D structure record. It is a peptide reference material, not a supplement, food or consumer product.
How does IGF-1 LR3 differ from IGF-1?
Native IGF-1 is the endogenous insulin-like growth factor 1. IGF-1 LR3 is an engineered analogue: the Long R3 modification (arginine at position 3 plus an N-terminal extension) is a structural change to the molecule. The two are distinct reference compounds. This describes what the molecules are, not any effect in a body.
Is IGF-1 LR3 legal in the UK?
IGF-1 LR3 is not a controlled drug under the Misuse of Drugs Act 1971 and may be supplied in the UK as a research chemical. It is not a licensed medicine and is not authorised for human or veterinary use. Kovalabs supplies it for laboratory research only. The buyer is responsible for lawful handling under applicable local regulations. See our research disclaimer.
How is identity and quality assured?
Each batch is released after independent analytical testing. Purity is assessed by HPLC at >= 99% and identity is confirmed against the expected mass for C400H625N111O115S9 (9117.6 g/mol). Not all material sold under this name is equivalent: confirm a current Certificate of Analysis. Batch documentation is available on our Certificates of Analysis page.
What does the research on IGF-1 LR3 investigate?
The published literature investigates IGF-1 receptor (IGF-1R) signalling and the growth-hormone / IGF axis in pre-clinical and in-vitro model systems. None of this establishes a benefit, effect or outcome in humans, and IGF-1 LR3 is not a licensed medicine. For mechanistic and study-design detail, see the IGF-1 LR3 research monograph; the product page covers identity, legality, quality and supply only.
Synthesis and supply
IGF-1 LR3 is supplied as a lyophilised white to off-white powder. For laboratory handling it is reconstituted in a suitable solvent such as bacteriostatic water. Store the lyophilised solid at -20C, dry and protected from light; hold reconstituted material at 2-8C. Browse the wider GH-axis research range or related reference peptides Ipamorelin, Sermorelin and GHRP-6. For laboratory research use only; not for human or veterinary use.
- 2D structure
- Product name
- IGF-1 LR3
- Synonyms
- Long R3 IGF-1, LR3 IGF-1
- Molecular formula
- C400H625N111O115S9
- Molecular weight
- 9117.6 g/mol
- CAS number
- 946870-92-4
- Purity
- >= 99% (HPLC)
- Form
- Lyophilised powder
- Appearance
- White to off-white solid
- Solubility
- Bacteriostatic water
- Storage
- Lyophilised: store at -20C, dry and light-protected. Reconstituted: 2-8C.
- What is IGF-1 LR3?
- IGF-1 LR3 (Long R3 IGF-1) is a recombinant 83-amino-acid analogue of insulin-like growth factor 1, CAS 946870-92-4, with molecular formula C400H625N111O115S9 and molecular weight 9117.6 g/mol. It differs from native IGF-1 by an arginine substitution at position 3 and an N-terminal extension. It is supplied as a lyophilised powder for laboratory research only.
- Is IGF-1 LR3 a peptide?
- Yes. IGF-1 LR3 is a recombinant peptide (protein), an 83-amino-acid analogue of insulin-like growth factor 1. It is supplied as a lyophilised reference material for laboratory research. It is not a supplement, food or consumer product, and it is not a licensed medicine.
- How is IGF-1 LR3 different from IGF-1?
- Native IGF-1 is the endogenous insulin-like growth factor 1. IGF-1 LR3 is an engineered analogue carrying the Long R3 modification: an arginine residue at position 3 plus a 13-residue N-terminal extension. The two are distinct molecules supplied as separate reference compounds. This describes what each molecule is, not any effect in a body.
- Is IGF-1 LR3 legal in the UK?
- IGF-1 LR3 is not a controlled drug under the Misuse of Drugs Act 1971 and may be supplied in the UK as a research chemical. It is not a licensed medicine and is not authorised for human or veterinary use. Kovalabs supplies it for laboratory research only, and the buyer is responsible for lawful handling under applicable regulations.
- Is IGF-1 LR3 for human use?
- No. IGF-1 LR3 is supplied strictly as a reference material for laboratory research. It is not a licensed medicine and is not intended, supplied or to be used for human or veterinary consumption or administration. No human or veterinary application is intended or implied.
- Has IGF-1 LR3 been shown to be safe or effective in humans?
- No. Published work on IGF-1 LR3 concerns IGF-1 receptor signalling and the GH/IGF axis in pre-clinical, in-vitro and animal model systems. None of it establishes a benefit, effect, safety profile or outcome in humans. IGF-1 LR3 is not a licensed medicine and must not be used to treat, prevent or diagnose any condition.
- What does the research on IGF-1 LR3 investigate?
- The literature investigates IGF-1 receptor (IGF-1R) signalling and the growth-hormone / IGF axis in laboratory model systems. These are mechanistic, non-clinical findings only and do not demonstrate any human effect or benefit. For study-design detail see the IGF-1 LR3 research monograph; this page covers identity, legality, quality and supply.
- Is all IGF-1 LR3 the same?
- No. Purity, identity and handling vary between suppliers and batches. Kovalabs releases each batch after independent testing, with purity assessed by HPLC at >= 99% and identity confirmed against the expected mass. Always confirm a current Certificate of Analysis before relying on any material.
- What are the molecular identifiers for IGF-1 LR3?
- IGF-1 LR3 is identified by CAS number 946870-92-4, molecular formula C400H625N111O115S9 and molecular weight 9117.6 g/mol. As a large recombinant protein it has no small-molecule PubChem 2D structure record. Synonyms include Long R3 IGF-1 and LR3 IGF-1.
- How is IGF-1 LR3 supplied and reconstituted?
- IGF-1 LR3 is supplied as a lyophilised white to off-white powder. For laboratory handling it is reconstituted in a suitable solvent such as bacteriostatic water. It is provided as a reference material for laboratory research only and is not intended for human or veterinary use.
- How should IGF-1 LR3 be stored?
- Store the lyophilised solid at -20C, kept dry and protected from light. Hold reconstituted material at 2-8C. Following appropriate storage helps preserve identity and purity for laboratory research. The material is for laboratory research use only.
- Is a Certificate of Analysis available for IGF-1 LR3?
- Yes. Each batch is released after independent identity and purity testing, with purity assessed by HPLC at >= 99% and identity confirmed against the expected mass for C400H625N111O115S9. Current batch Certificates of Analysis are available on the Kovalabs CoA page.
- Where can I buy IGF-1 LR3 in the UK?
- IGF-1 LR3 is available from Kovalabs for UK research customers, supplied as a lyophilised powder with batch testing and UK despatch. It is provided for laboratory research use only and is not for human or veterinary use. Confirm the Certificate of Analysis before purchase.
- How does IGF-1 LR3 compare to Ipamorelin or Sermorelin?
- They are distinct molecules within GH-axis research. IGF-1 LR3 is a recombinant IGF-1 analogue, while Ipamorelin and Sermorelin are separate research peptides studied in the growth-hormone axis. Each is supplied as its own reference material for laboratory research only. This describes what the molecules are, not any effect in a body.
No third-party batch reports have been uploaded for this product yet. Reports are issued by independent labs after each manufacturing batch.
Calculator
Research planning only
Concentration0.50 mg/ml
Volume to draw0.500 ml
Insulin syringe (100 IU/ml)
50.0units
For research planning only. Not medical, dosing, or therapeutic advice. All Kovalabs products are research-use-only.
Store unreconstituted vials at −20°C for long-term, or refrigerated at 2-8°C for short-term use. Avoid repeated freeze-thaw cycles.
Reconstitute with bacteriostatic water down the inside wall of the vial; gently swirl to dissolve. Do not shake.
Once reconstituted, refrigerate at 2-8°C and use within 2-4 weeks. Discard if cloudy, discoloured, or particulate.