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Metabolic
MOTS-C
- Purity
- >= 99% (HPLC)
- Form
- Lyophilised powder
- Origin
- United States
Manufactured for laboratory research. Not for human or veterinary use. Read full disclaimer →
MOTS-C is a mitochondrial-derived peptide studied in research into metabolic homeostasis and AMPK-pathway signalling in experimental models.
- Purity >= 99% (HPLC)
- Supplied as a lyophilised powder
- Independent batch identity and purity testing
- For laboratory research use only; not for human or veterinary use
What is MOTS-c?
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. It carries CAS number 1627580-64-6, molecular formula C101H152N28O22S2 and a molecular weight of 2174.6 g/mol. Kovalabs supplies it as a lyophilised research material.
The peptide sequence is Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg, and it is catalogued in PubChem under CID 146675088. It is a reference compound for non-clinical laboratory work, not a consumer product and not a medicine.
Is MOTS-c legal in the UK?
MOTS-c is not a controlled drug under the Misuse of Drugs Act 1971 and it is not a scheduled substance. It is supplied strictly as a research chemical for laboratory use only. It is not authorised as a medicine in the UK, cannot be sold or bought for human or veterinary consumption, and the purchaser is responsible for handling, storage and compliance with the conditions set out in our research disclaimer.
How is identity and quality assured?
Each batch of MOTS-c is released after independent analytical testing. Purity is assessed at 99% or greater by HPLC, and identity is confirmed against the expected mass for C101H152N28O22S2 (2174.6 g/mol). The verified identifiers (CAS 1627580-64-6, PubChem CID 146675088) let researchers cross-check the material against public databases.
A certificate of analysis accompanies every batch. You can review documentation on the CoA page to confirm the lot you receive matches the stated identity and purity before any research use.
What does the research on MOTS-c investigate?
The published literature studies MOTS-c as a signalling peptide in the mitochondrial and AMPK research pathway, using in-vitro and animal model systems. These are pre-clinical observations only: none of this establishes a benefit, effect or outcome in humans, and MOTS-c is not a licensed medicine.
For the mechanistic background and the cited studies, see the research monograph at MOTS-c: a mitochondrial-derived peptide in research. That article handles the evidence in depth; this product page covers identity, legality, quality and supply.
Synthesis and supply
MOTS-c is manufactured to research grade and shipped as a white to off-white lyophilised powder. For bench work it is reconstituted in a suitable solvent such as bacteriostatic water; store the lyophilised solid at -20C, dry and protected from light, and hold reconstituted material at 2-8C.
MOTS-c sits in the metabolic research category alongside other mitochondrial and metabolic-pathway reference compounds. Related research materials in the catalogue include retatrutide and cagrilintide. All are supplied for laboratory research use only, not for human or veterinary use.
- 2D structure
- Product name
- MOTS-c
- Synonyms
- Mitochondrial ORF of the 12S rRNA type-c
- Sequence
- Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.6 g/mol
- CAS number
- 1627580-64-6
- PubChem CID
- 146675088
- Purity
- >= 99% (HPLC)
- Form
- Lyophilised powder
- Appearance
- White to off-white solid
- Solubility
- Bacteriostatic water
- Storage
- Lyophilised: store at -20C, dry and light-protected. Reconstituted: 2-8C.
- What is MOTS-c?
- MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. It has CAS number 1627580-64-6, molecular formula C101H152N28O22S2 and molecular weight 2174.6 g/mol. Kovalabs supplies it as a lyophilised reference compound for laboratory research only.
- Is MOTS-c legal in the UK?
- MOTS-c is not a controlled drug under the Misuse of Drugs Act 1971 and is not a scheduled substance. It is legal to supply in the UK as a research chemical for laboratory use only. It is not authorised as a medicine, cannot be sold or purchased for human or veterinary consumption, and the buyer is responsible for lawful handling and storage.
- Is MOTS-c intended for human use?
- No. MOTS-c is supplied strictly for laboratory research use only. It is not a medicine, not a supplement and not for human or veterinary consumption. No human or veterinary application is intended or implied, and it must not be administered to people or animals.
- Has MOTS-c been shown to be safe or effective in humans?
- No. The published research on MOTS-c is pre-clinical, conducted in in-vitro and animal model systems. None of it establishes safety, efficacy, a benefit, an effect or an outcome in humans. MOTS-c is not a licensed medicine and no human claims can be made for it.
- What is MOTS-c studied for in research?
- The literature investigates MOTS-c as a signalling peptide in the mitochondrial and AMPK research pathway, in laboratory and animal models. These are research-context observations only and do not establish any human benefit or effect. The mechanistic detail and cited studies are covered in our MOTS-c research monograph linked from the product page.
- What is the MOTS-c peptide sequence?
- The MOTS-c amino-acid sequence is Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg, a 16-residue peptide. It carries the molecular formula C101H152N28O22S2 with a molecular weight of 2174.6 g/mol, consistent with its mitochondrial-derived origin.
- What are the molecular identifiers for MOTS-c?
- MOTS-c is identified by CAS number 1627580-64-6 and PubChem CID 146675088. Its molecular formula is C101H152N28O22S2 and its molecular weight is 2174.6 g/mol. These identifiers let researchers cross-reference the material against public chemical databases such as PubChem.
- Is all MOTS-c the same?
- No. Purity and identity vary by supplier and batch, which is why analytical documentation matters. Kovalabs releases each MOTS-c batch only after independent testing showing 99% or greater purity by HPLC and identity confirmed against the expected mass. A certificate of analysis is provided so you can verify the specific lot.
- Does MOTS-c come with a certificate of analysis?
- Yes. Every batch of MOTS-c ships with a certificate of analysis reporting purity (99% or greater by HPLC) and confirmed identity against the expected mass for C101H152N28O22S2. You can review CoA documentation on our CoA page to confirm the lot matches the stated identity before any research use.
- How is MOTS-c supplied and reconstituted?
- MOTS-c is supplied as a white to off-white lyophilised powder. For bench work it is reconstituted in a suitable solvent such as bacteriostatic water, which Kovalabs also stocks. It is a research reagent prepared for laboratory use; reconstitution is a bench step and the material is not for administration to humans or animals.
- How should MOTS-c be stored?
- Store the lyophilised MOTS-c powder at -20C, kept dry and protected from light. Once reconstituted, hold the solution at 2-8C. Proper storage preserves the integrity of the peptide for laboratory research. The material is for research use only, not for human or veterinary use.
- Is MOTS-c a peptide or a small molecule?
- MOTS-c is a peptide: a 16-amino-acid chain (sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg) derived from the mitochondrial 12S rRNA region. It is not a steroid or a small-molecule drug. Its formula C101H152N28O22S2 and weight 2174.6 g/mol reflect its peptide structure.
- How does MOTS-c compare with other metabolic research peptides?
- MOTS-c is a mitochondrial-derived peptide studied in the AMPK research pathway, which is a distinct molecule from incretin and amylin-class research compounds such as retatrutide and cagrilintide. Each is a different chemical with its own identifiers and is supplied separately for laboratory research use only, not for human use.
- Where can I buy MOTS-c in the UK?
- Kovalabs supplies MOTS-c in the UK as a research chemical, despatched from the UK with a certificate of analysis for each batch. It is sold for laboratory research use only, not for human or veterinary consumption. See the metabolic research category for related reference compounds in the catalogue.
No third-party batch reports have been uploaded for this product yet. Reports are issued by independent labs after each manufacturing batch.
Calculator
Research planning only
Concentration5.00 mg/ml
Volume to draw0.050 ml
Insulin syringe (100 IU/ml)
5.0units
For research planning only. Not medical, dosing, or therapeutic advice. All Kovalabs products are research-use-only.
Store unreconstituted vials at −20°C for long-term, or refrigerated at 2-8°C for short-term use. Avoid repeated freeze-thaw cycles.
Reconstitute with bacteriostatic water down the inside wall of the vial; gently swirl to dissolve. Do not shake.
Once reconstituted, refrigerate at 2-8°C and use within 2-4 weeks. Discard if cloudy, discoloured, or particulate.
