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Tissue Repair
TB-500
- Purity
- >= 99% (HPLC)
- Form
- Lyophilised powder
- Origin
- United States
Manufactured for laboratory research. Not for human or veterinary use. Read full disclaimer →
TB-500 is a synthetic fragment of thymosin beta-4 studied in research into actin regulation, cell-migration and tissue-repair pathways in experimental models.
- Purity >= 99% (HPLC)
- Supplied as a lyophilised powder
- Independent batch identity and purity testing
- For laboratory research use only; not for human or veterinary use
What is TB-500?
TB-500 is a synthetic acetylated heptapeptide with the sequence Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ), corresponding to the actin-binding region of the larger thymosin beta-4 protein. It carries the molecular formula C38H68N10O14, a molecular weight of 889.0 g/mol, and CAS number 885340-08-9. It is supplied as a lyophilised powder for laboratory research.
The naming is a common source of confusion. "TB-500" is widely used as shorthand for thymosin beta-4 itself, but the defined chemical entity sold under that name is the short heptapeptide fragment, not the full 43-residue protein. The two are not interchangeable and do not share a mass, so molecular weight is the reliable way to tell them apart.
Is TB-500 legal in the UK?
TB-500 is not a controlled drug under the Misuse of Drugs Act 1971, and it is not a licensed medicine in the UK. It is supplied strictly as a research chemical for in vitro and laboratory investigation. It cannot lawfully be sold or supplied for human consumption, and it is not intended to diagnose, treat, cure or prevent any condition. Responsibility for lawful and appropriate handling rests with the purchaser. See our research disclaimer for the full terms.
How is the identity and quality assured?
Verify, do not trust. Every batch is released against a Certificate of Analysis confirming identity and purity by HPLC. Identity should reconcile to the verified identifiers for the heptapeptide: CAS 885340-08-9, PubChem CID 62707662, formula C38H68N10O14, and a molecular weight of 889.0 g/mol. Mass is the decisive check here, because material mislabelled as TB-500 is sometimes the full thymosin beta-4 protein, which carries a very different mass. Current documentation is available on our Certificates of Analysis page.
What does the research on TB-500 investigate?
The fragment derives from thymosin beta-4, a protein examined in laboratory models of actin sequestration and cell migration. That an investigational area exists is not evidence of an outcome: none of this work establishes a safety or efficacy result for TB-500 in humans, and the peptide has not been evaluated as a medicine. The detailed evidence audit, including how the heptapeptide relates to the parent protein, is handled in the monograph at our TB-500 research review, with the comparative literature covered in BPC-157 vs TB-500.
Synthesis and supply
TB-500 is supplied as a lyophilised powder, reconstituted for laboratory work with a suitable solvent such as bacteriostatic water. It sits within our tissue-repair research range alongside BPC-157 and GHK-Cu, peptides frequently examined in the same literature. All material ships from the UK with batch documentation.
- 2D structure
- Product name
- TB-500
- Synonyms
- Thymosin beta-4 (17-23) fragment, Ac-LKKTETQ
- Sequence
- Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln
- Molecular formula
- C38H68N10O14
- Molecular weight
- 889.0 g/mol
- CAS number
- 885340-08-9
- PubChem CID
- 62707662
- Purity
- >= 99% (HPLC)
- Form
- Lyophilised powder
- Appearance
- White to off-white solid
- Solubility
- Bacteriostatic water
- Storage
- Lyophilised: store at -20C, dry and light-protected. Reconstituted: 2-8C.
- What is TB-500?
- TB-500 is a synthetic acetylated heptapeptide, sequence Ac-LKKTETQ, corresponding to the actin-binding region of thymosin beta-4. It has the formula C38H68N10O14, a molecular weight of 889.0 g/mol, and CAS number 885340-08-9. It is supplied as a lyophilised powder for laboratory research only.
- Is TB 500 the same as thymosin beta-4?
- No. Thymosin beta-4 is a 43-residue protein. The defined TB-500 entity is the short acetylated heptapeptide Ac-LKKTETQ, a fragment of that protein, not the whole molecule. They have different molecular weights, so mass is the reliable way to tell them apart. Material labelled TB-500 is occasionally the full protein, which is why identity should be confirmed against the Certificate of Analysis.
- Is TB 500 legal in the UK?
- TB-500 is not a controlled drug under the Misuse of Drugs Act 1971 and is not a licensed medicine. It is sold strictly as a research chemical and cannot lawfully be supplied for human consumption. Responsibility for lawful handling rests with the purchaser. See our research disclaimer for the full terms.
- Is TB 500 intended for human use?
- No. TB-500 is supplied for in vitro and laboratory research use only. It is not a food, supplement or medicine, is not intended for human or veterinary consumption, and must not be used to diagnose, treat, cure or prevent any condition.
- Has TB-500 been shown to be safe in humans?
- No. TB-500 has not been evaluated for safety in humans and is not approved for human use. Any references in the scientific literature describe laboratory or preclinical investigation only and do not establish a safety profile for human use.
- Does TB-500 have side effects?
- There is no established human side-effect profile for TB-500, because it has not been evaluated for safety in humans and is not approved for human use. It is supplied for laboratory research only and is not intended for human or veterinary consumption, so any discussion of effects in people would be outside the basis on which it is sold.
- What does the research on TB-500 investigate?
- The parent protein, thymosin beta-4, has been examined in laboratory models of actin regulation and cell migration. The existence of these research areas is not evidence of an outcome: no study establishes an efficacy or safety result for TB-500 in humans. A fuller account is given in our TB-500 research review on the blog.
- Is TB 500 banned in sport?
- Yes. Peptides in the thymosin beta-4 family, including TB-500, are listed on the WADA Prohibited List. Anyone subject to anti-doping regulation should treat the material accordingly. This is stated as a matter of fact and is independent of the research-use-only basis on which it is supplied.
- What are the molecular identifiers for TB-500?
- The defined TB-500 heptapeptide has CAS number 885340-08-9, PubChem CID 62707662, molecular formula C38H68N10O14, molecular weight 889.0 g/mol, and sequence Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ).
- How is TB-500 supplied and reconstituted?
- TB-500 is supplied as a lyophilised powder. For laboratory work it is reconstituted with a suitable solvent such as bacteriostatic water. Reconstitution is a standard laboratory step; the material remains for research use only and is not for human consumption.
- How should TB-500 be stored?
- Lyophilised TB-500 is typically kept sealed, cool and away from light and moisture, with colder storage for longer-term holding. Once reconstituted, peptide solutions are generally kept refrigerated and used within a limited period. Follow the storage guidance on the Certificate of Analysis for the specific batch.
- How is the purity and identity of TB-500 verified?
- Each batch is released with a Certificate of Analysis confirming identity and purity by HPLC. The verified identifiers and, in particular, the molecular weight of 889.0 g/mol distinguish the heptapeptide fragment from the full thymosin beta-4 protein. Current documents are on our Certificates of Analysis page.
- What is the difference between TB-500 and BPC-157?
- They are different molecules. TB-500 is a synthetic acetylated heptapeptide, Ac-LKKTETQ, derived from the actin-binding region of thymosin beta-4, formula C38H68N10O14, 889.0 g/mol. BPC-157 is a separate 15-residue pentadecapeptide derived from a gastric protein fragment, with its own distinct sequence and mass. They are not the same compound and are not interchangeable. Both are supplied as separate research chemicals for laboratory use only, not for human consumption.
- Are BPC-157 and TB-500 the same thing, and why are they often mentioned together?
- No, they are two distinct peptides with different sequences and molecular weights. They are often named together because both derive from larger endogenous proteins and appear in the same area of laboratory literature, so they are frequently studied side by side. The co-occurrence of a research topic is not evidence of any outcome, and neither has been evaluated as a medicine in humans. Kovalabs supplies them as separate research chemicals, each released against its own Certificate of Analysis.
No third-party batch reports have been uploaded for this product yet. Reports are issued by independent labs after each manufacturing batch.
Calculator
Research planning only
Concentration2.50 mg/ml
Volume to draw0.100 ml
Insulin syringe (100 IU/ml)
10.0units
For research planning only. Not medical, dosing, or therapeutic advice. All Kovalabs products are research-use-only.
Store unreconstituted vials at −20°C for long-term, or refrigerated at 2-8°C for short-term use. Avoid repeated freeze-thaw cycles.
Reconstitute with bacteriostatic water down the inside wall of the vial; gently swirl to dissolve. Do not shake.
Once reconstituted, refrigerate at 2-8°C and use within 2-4 weeks. Discard if cloudy, discoloured, or particulate.
