Kisspeptin-10

What is Kisspeptin-10?

Kisspeptin-10 is a synthetic decapeptide corresponding to residues 112-121 of the human KISS1 gene product, and an agonist at the kisspeptin receptor KISS1R (also catalogued as GPR54). Its sequence is Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (YNWNSFGLRF-NH2), with molecular formula C63H83N17O14, molecular weight 1302.4 g/mol and CAS number 374675-21-5. It also appears in the literature as metastin 45-54. Kovalabs supplies it lyophilised as a research reference compound for laboratory use only.

The amide-capped C-terminal Arg-Phe motif is the part of the sequence the literature identifies as required for receptor recognition, and is characteristic of its identity within the RFamide peptide family. Kisspeptin-10 sits in the neuropeptides research category as a reference material, not as a medicine or supplement.

Is Kisspeptin-10 legal in the UK?

Kisspeptin-10 is not a controlled drug under the Misuse of Drugs Act 1971 and is not scheduled. It is supplied in the UK strictly as a research chemical for laboratory use only. It is not a licensed medicine, holds no marketing authorisation, and cannot be sold or supplied for human or veterinary consumption. The buyer is responsible for lawful, compliant handling under their own jurisdiction. See our research disclaimer.

How is identity and quality assured?

Each batch is released after independent testing. Purity is assessed by HPLC at 99% or greater, and identity is confirmed by HPLC retention-time matching (HPLC-RTM) against a reference standard for C63H83N17O14 (CAS 374675-21-5, PubChem CID 25240297). A batch-specific Certificate of Analysis accompanies the material; current documents are published on our CoA page. This verification is what separates a characterised reference compound from unverified material, which is why "is all kisspeptin the same" has a clear answer: only a CoA-backed batch is.

What does the research on Kisspeptin-10 investigate?

The published literature uses Kisspeptin-10 as a tool compound to probe KISS1R / GPR54 binding and the intracellular cascades it recruits, including ERK1/2 phosphorylation and calcium signalling, in receptor-transfected cell systems and in isolated hypothalamic GnRH neurons. Structure-activity work across kisspeptin analogues maps which residues drive receptor affinity. People searching for kisspeptin benefits or effects should note that none of this establishes any benefit, effect or outcome in humans; it is not a licensed medicine and no human or veterinary application is intended or implied.

How does Kisspeptin-10 compare with other neuropeptides?

Kisspeptin-10 acts at KISS1R, a receptor distinct from those studied with the other neuropeptides in this catalogue: Selank and Semax are short regulatory peptides investigated in separate central-signalling literature, and DSIP is a nonapeptide studied in its own right. PT-141 is a melanocortin-receptor ligand and is again mechanistically separate. These are identity and receptor comparisons only, not protocols and not any guidance for use in a body.

Synthesis and supply

Kisspeptin-10 is supplied as a white to off-white lyophilised solid for reconstitution at the bench with a research solvent such as bacteriostatic water. Store lyophilised material at -20C, dry and protected from light; hold reconstituted material at 2-8C. Sold per vial as a product specification, despatched from the UK. For laboratory research use only; not for human or veterinary use.